Post-Doctoral Fellow - Military HIV Research Program - Silver Spring, MD

Updated: Today
Job ID: 215717
Status: Full-Time
Regular/Temporary: Regular
Location: Silver Spring, MD, United States

Join the HJF Team!

HJF is seeking a Post-Doctoral Fellow to support the Military HIV Research Program (MHRP) located at the Walter Reed Army Institute of Research (WRAIR) in Silver Spring, MD. HJF provides scientific, technical and programmatic support services to MHRP.

The incumbent will assist in designing, developing, and executing research projects involving HIV-1 antigens and candidate HIV-1 vaccines. Incumbent works with minimum supervision and investigates the bio-molecular and functional interactions between HIV-1 particles, cells, and recombinant proteins with monoclonal and polyclonal antibodies using state-of-the-art immunological, biochemical, and molecular biology techniques. Incumbent will also utilize cell culture and flow cytometry-based assays.  Should have knowledge and extensive experience in humoral and cellular immunology, sterile tissue and cell culture, flow cytometry, immunological assays, and PCR techniques. Incumbent should have strong communication skills in written and verbal English.  May also require minimal small animal handling. 

Responsibilities: 

  1. Plans, designs, and conducts laboratory research in the field of HIV-1 vaccine development including studies on adjuvant and antigen formulation, delivery, antigen presentation, and immune responses to HIV infection and vaccine-induced immune responses that will lead to high impact scientific publications. 
  2. Assists with the purification of HIV-1 and studies the interactions of HIV-1 and recombinant antigens and vaccine candidates with primary cells and cell lines.
  3. Designs studies in small animals, humanized mice, and nonhuman primates for the development of HIV-1 vaccines using various vaccine candidates and analyzes cellular, humoral, mucosal, and neutralizing immune responses to HIV-1 antigens, and candidate HIV-1 vaccines.
  4. Analyzes human and nonhuman primate clinical samples for the presence of HIV-1 specific binding and functional antibodies.
  5. Characterizes the antibodies for functionality using cell-based and immunological assays such as antibody-dependent cytotoxicity (ADCC), virus neutralization, inhibition of integrin binding, inhibition of phagocytosis, and virus capture and/or develops new techniques to assess antibody functions.
  6. Utilizes methods to demonstrate the changes in HIV-1 envelope protein upon binding to cells or antibodies.
  7. Works as a team member in assisting in studies related to immune responses to HIV-1 antigens and candidate HIV-1 vaccines.
  8. Develops necessary technologies and protocols, performs data analysis, prepares graphical representation of data, prepares manuscripts for publication in peer reviewed scientific journals, assists in the preparation of scientific reports for funded projects, presents research data at in-house meetings and at National and International scientific conferences.
  9. Assists in the preparation of funding applications for the U.S. Army Medical Research and Materiel Command, and/or extramural resources including nonprofit organizations.
  10. Maintains expertise and knowledge of state-of-the-art principles and theories directly applicable to the research work being conducted.  Should have knowledge and extensive experience in humoral and cellular immunology, sterile tissue and cell culture, flow cytometry, and biochemical techniques and be well versed in relevant literature.
  11. Attends all training and safety classes conducted by WRAIR and HMJF.
  12. Assists with animal immunizations and bleeds when required.
  13. Completes other projects and duties as assigned.

Required Knowledge, Skills, and Abilities: Knowledge of highly complex scientific procedures, techniques, fundamental immunology and familiarity with infectious disease concepts, especially HIV; knowledge and practical experience in flow cytometry, humoral and cellular immunology, tissue culture, biochemistry, biacore, purification of proteins, ELISA, molecular biology techniques, and computational skills. Should have excellent communication skills including the ability to write research papers and grants and a strong motivation to conduct research. Should have the ability to work with minimum supervision, be able to design experiments, analyze data, and troubleshoot technical procedures and supervise technical staff.

Minimum Education/Training Requirements:  Ph.D. in related scientific discipline required. 

Minimum Experience: 0-5 years of related post-doctoral research experience required.

Physical Capabilities: Work involves long periods of standing, handling numerous chemicals and biological samples in the laboratory.

Work Environment:  Laboratory environment; requires working with HIV-1 and blood or bodily fluids; requires minimal small animal handling, may require working long hours including evenings and weekends; involves working with chemicals.

Background/Security: Must have lived in the US 3 out of the past 5 years; eligible to pass a NACI background.

Employment with HJF is contingent upon successful completion of a background check, which may include, but is not limited to, contacting your professional references, verification of previous employment, addresses, education, and credentials, a criminal background check, drug screening, and a department of motor vehicle (DMV) check.  

HJF is an equal opportunity and affirmative action employer.  All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status.

Any qualifications to be considered as equivalents, in lieu of stated minimums, require the prior approval of the Chief Human Resources Officer.
 

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